facebook linkedin twitter

CDC Interim Estimates Find Moderna Vaccines Most Effective Against Delta Breakthroughs

September 15, 2021 by Reece Nations
The CDC′s Tom Harkin Global Communications Center located on the organization′s Roybal Campus in Atlanta, Georgia. (Photo Credit: James Gathany, Centers for Disease Control and Prevention)

WASHINGTON — Data collected by the Centers for Disease Control and Prevention on COVID-19’s delta variant found that vaccine efficacy was higher among recipients of the Moderna vaccination at 95%, higher than both the Pfizer-BioNTech and the Johnson & Johnson vaccines.

The CDC collected data in a multistate interim analysis of 32,867 medical encounters from a wide range of adults between June and August. In its findings, the CDC found that recipients of the Pfizer vaccine demonstrated 80% effectiveness at preventing breakthrough infection while the J&J vaccine showed 60% effectiveness.

Patients who had not received any COVID-19 vaccine doses were considered unvaccinated, and those who had received one mRNA dose only or their second dose fewer than 14 days before testing or the encounter date were excluded from the study. Out of the adults in the study who experienced emergency department or urgent care visits for “COVID-19–like [illnesses],” positive cases were identified among 7% of fully vaccinated patients and 28.9% of unvaccinated patients.

“[Vaccine effectiveness] was adjusted for age, geographic region, calendar time, and virus circulation, and weighted for inverse propensity to be vaccinated or unvaccinated,” CDC officials said in the report. “[Vaccine effectiveness] estimates with 95% confidence intervals that did not overlap were considered statistically different. This activity was reviewed by CDC and was conducted consistent with applicable federal law and CDC policy.”

The CDC utilized the “VISION Network” to examine medical encounters from 187 hospitals and 221 emergency departments and urgent care clinics across nine states starting on the date when the delta variant accounted for over 50% of COVID-19 cases in each medical facility’s respective state. Vaccination status of the patients in the study was documented in electronic health records and immunization registries.

The VISION Network is comprised of Columbia University Irving Medical Center in New York, HealthPartners in Minnesota and Wisconsin, Intermountain Healthcare in Utah, Kaiser Permanente Northern California, Kaiser Permanente Northwest in Oregon and Washington, Regenstrief Institute in Indiana and the University of Colorado. The median age of patients in the study was 43 years, and the interquartile range was between 29 and 62 years old.

“The findings in this report are subject to at least three limitations,” CDC officials said in the report. “First, [vaccine effectiveness] by time since vaccination was not examined; further evaluation of possible waning of vaccine protection is currently underway. Second, [vaccine effectiveness] for partial vaccination was not assessed. Finally, although the facilities in this study serve heterogeneous populations in nine states, the findings might not be generalizable to the U.S. population.”

Overall vaccine effectiveness estimates were roughly equivalent to those during the months before the delta variant became predominant in the country, although their effectiveness among adults older than 75 years was lower than adults younger than 75 years. This discrepancy in effectiveness by age “should be interpreted with caution” and could be related to mutations of the virus, waning immunity over the course of time or a combination of factors.

Vaccine effectiveness against emergency department and urgent care clinic encounters overall was 82%, and effectiveness against COVID-19 hospitalization was 86%, according to the CDC’s report. The CDC concluded in its report that further examination of the “magnitude and sources of product-specific” differences in vaccine effectiveness is warranted.

“These findings reaffirm the high protection of COVID-19 vaccines against moderate and severe COVID-19 resulting in [emergency department], [urgent care], and hospital visits and underscore the importance of full COVID-19 vaccination and continued benefits of COVID-19 vaccination during Delta variant predominance,” CDC officials said in the report. 

Health

September 17, 2021
by Dan McCue
FDA Panel Backs COVID-19 Boosters Only for Elderly, Those at High-Risk

WASHINGTON - A Food and Drug Administration advisory panel voted unanimously Friday to recommend emergency use authorization of a booster... Read More

WASHINGTON - A Food and Drug Administration advisory panel voted unanimously Friday to recommend emergency use authorization of a booster dose of Pfizer-BioNTech COVID-19 vaccine six months after full vaccination in people 65 and older and those at high risk of severe Covid-19. But the same... Read More

September 15, 2021
by Reece Nations
CDC Interim Estimates Find Moderna Vaccines Most Effective Against Delta Breakthroughs

WASHINGTON — Data collected by the Centers for Disease Control and Prevention on COVID-19's delta variant found that vaccine efficacy... Read More

WASHINGTON — Data collected by the Centers for Disease Control and Prevention on COVID-19's delta variant found that vaccine efficacy was higher among recipients of the Moderna vaccination at 95%, higher than both the Pfizer-BioNTech and the Johnson & Johnson vaccines. The CDC collected data in... Read More

September 15, 2021
by Alexa Hornbeck
U.S. Health System Trails Far Behind Other High-income Countries

The COVID-19 pandemic has shown that no nation has the perfect health system, but a report from the Commonwealth Fund... Read More

The COVID-19 pandemic has shown that no nation has the perfect health system, but a report from the Commonwealth Fund finds the U.S. trails far behind other high-income countries on measures of health care affordability, administrative efficiency, equity, and outcomes. By analyzing 11 high-income countries and... Read More

September 15, 2021
by Alexa Hornbeck
Study: Getting Vaccinated Against COVID-19 Can Improve Mental Health

LOS ANGELES, Calif. -- A year-long study conducted by researchers from the University of Southern California finds that getting vaccinated... Read More

LOS ANGELES, Calif. -- A year-long study conducted by researchers from the University of Southern California finds that getting vaccinated against COVID-19 can actually improve mental health. “We were interested to see what the short-term effects of getting a COVID-19 vaccination would be on people’s mental... Read More

President, CEOs, Biz Leaders Meet on COVID-19 Vaccine Mandates

WASHINGTON (AP) — President Joe Biden was meeting Wednesday with the CEOs of Walt Disney and Columbia Sportswear, and other... Read More

WASHINGTON (AP) — President Joe Biden was meeting Wednesday with the CEOs of Walt Disney and Columbia Sportswear, and other business executives and leaders leaders to discuss  his recently announced vaccine requirement for companies  that employ at least 100 people.  The White House meeting comes less... Read More

Biden: Nearly 3M Get Health Coverage During COVID-19 Sign-Up

WASHINGTON (AP) — Nearly 3 million consumers took advantage of a special six-month period to sign up for subsidized health... Read More

WASHINGTON (AP) — Nearly 3 million consumers took advantage of a special six-month period to sign up for subsidized health insurance coverage made more affordable by the COVID-19 relief law, President Joe Biden said Wednesday. He called that number encouraging and urged Congress to help keep... Read More

News From The Well
scroll top