Preclinical Data Shows Ability of Antibody Combo to Neutralize Omicron Variants

March 23, 2022 by Alexa Hornbeck
Preclinical Data Shows Ability of Antibody Combo to Neutralize Omicron Variants

This week, researchers from Washington University School of Medicine released preclinical data that shows a long-acting antibody combination called Evusheld can neutralize activity against omicron variants of the COVID-19 virus, including BA.2.

To conduct the study, researchers used in vivo data generated using mice infected with omicron BA.1 and BA.2 to demonstrate that Evusheld could significantly reduce the viral burden and limit inflammation in the lungs for both subvariants. 

The data shows that Evusheld’s ability to reduce omicron’s viral load may also decrease the likelihood of severe infection or death, as well as long-COVID symptoms. 

Evusheld was developed by AstraZeneca with support from the U.S. government and funds from the Department of Health and Human Services. 

The treatment received emergency use authorization in the U.S. in December 2021 for preventing COVID-19 in people who are moderately to severely immunocompromised due to a medical condition or immunosuppressive medication.

The findings about Evusheld come after previous studies showed the omicron variant can escape certain antibody combinations.

A study published in Nature Medicine on Jan. 19 finds that several antibody combinations in clinical use by Celltrion, Regeneron and Eli Lilly had completely lost the ability to neutralize the omicron variant in cell culture. 

Alexa can be reached at [email protected]

A+
a-

In The News

Health

Voting

Health

May 24, 2024
by Dan McCue
Drowning Deaths On the Rise in the United States

WASHINGTON — After decades of decline, drowning deaths are once again on the rise in the United States, according to... Read More

WASHINGTON — After decades of decline, drowning deaths are once again on the rise in the United States, according to a new Vital Signs study by the Centers for Disease Control and Prevention. Over 4,500 people died due to drowning each year from 2020 to 2022,... Read More

HPV Vaccines Prevent Cancer in Men as Well as Women, New Research Suggests

New research suggests the HPV vaccine is preventing cancer in men, as well as in women, but fewer boys than... Read More

New research suggests the HPV vaccine is preventing cancer in men, as well as in women, but fewer boys than girls are getting the shots in the United States. The HPV vaccine was developed to prevent cervical cancer in women and experts give it credit, along... Read More

Black Americans Underrepresented in Residential Care Communities, AP/CNHI News Analysis Finds

Norma Upshaw was living alone south of Nashville when her doctor said she needed to start in-home dialysis. Her closest... Read More

Norma Upshaw was living alone south of Nashville when her doctor said she needed to start in-home dialysis. Her closest family lived 40 miles away, and they’d already scrambled once when the independent senior living facility the 82-year-old had called home — a community of largely... Read More

May 22, 2024
by Dan McCue
CDC Identifies Second Human Bird Flu Case in US

ATLANTA — A Michigan farmworker became the second individual in the United States this year confirmed to have contracted the... Read More

ATLANTA — A Michigan farmworker became the second individual in the United States this year confirmed to have contracted the bird flu after exposure to infected livestock, the Centers for Disease Control and Prevention announced Wednesday. The individual had only mild symptoms of infection with the... Read More

May 22, 2024
by Dan McCue
Senators Say State Abortion Ban Causing Exodus of Women’s Health Care Providers

WASHINGTON — A trio of Democratic senators assailed abortion bans in Republican-led states on Tuesday, pointing to a new report... Read More

WASHINGTON — A trio of Democratic senators assailed abortion bans in Republican-led states on Tuesday, pointing to a new report that suggests those laws are forcing women’s health care providers to turn away patients, shut down practices and abandon those states altogether for fear of prosecution... Read More

May 22, 2024
by Jesse Zucker
Strength Training May Improve Mental Health

WASHINGTON — Do you generally feel good after exercise? It has been well-documented that getting regular physical activity may improve... Read More

WASHINGTON — Do you generally feel good after exercise? It has been well-documented that getting regular physical activity may improve mental health and help decrease symptoms of depression and anxiety, but how does it work? Most research focuses on how cardio exercise impacts mental health. Less... Read More

News From The Well
scroll top