Anti-Abortion Activists Aim to Sway GOP White House Hopefuls
Experimental Cancer Vaccine Shows Promise in Animal Studies
November 15, 2022 by TWN Staff
WASHINGTON — An experimental therapeutic cancer vaccine induced two distinct and desirable immune system responses that led to significant tumor regression in mice, according to investigators from the National Institute of Allergy and Infectious Diseases.
The experimental vaccine, SNAPvax, was designed by Robert Seder, M.D., and colleagues at the NIAID Vaccine Research Center together with collaborators from Vaccitech North America, a clinical-stage biopharmaceutical company in Baltimore, Maryland.
The researchers found that intravenous administration of the vaccine boosted the number of cytotoxic T cells capable of infiltrating and attacking tumor cells and engaged the innate immune system by inducing type I interferon.
The innate immune response modified the tumor microenvironment, counteracting suppressive forces that otherwise would tamp down T-cell action. Modification of the tumor microenvironment was not seen in mice that received the vaccine via needle injection into the skin.
Dubbed “vax-innate” by the scientific team, the approach achieves an important goal in the quest for more effective immunotherapeutic vaccines for cancer.
The study demonstrates that IV vaccine delivery enables and enhances T-cell immunity by overcoming tumor-induced immunosuppressive activity.
The researchers say the candidate vaccine might also be given intravenously to people who have already received tumor-specific T cells as a therapy. It also could improve tumor control by increasing the number of T cells and altering the tumor microenvironment to make them function better, the researchers note.
Vaccitech announced plans to advance the SNAPvax platform for use in treating human papillomavirus associated cancer in 2023.
In The News
In The News
Lawmakers Want Justice Department to Investigate More Trump Supporters
2023-02-03 20:35:39
Health
Voting
Health
February 1, 2023
by Anti-Abortion Activists Aim to Sway GOP White House Hopefuls
Anti-Abortion Activists Aim to Sway GOP White House Hopefuls
CHICAGO (AP) — Emboldened anti-abortion activists are looking to the 2024 presidential election as an opportunity to solidify their influence over the... Read More
CHICAGO (AP) — Emboldened anti-abortion activists are looking to the 2024 presidential election as an opportunity to solidify their influence over the Republican Party. Susan B. Anthony Pro-Life America, the most influential group in the anti-abortion movement, is telling each potential GOP presidential hopeful that to win its... Read More
February 1, 2023
by Eden Metzger
Hawaiian Senator Seeks to Crack Down on Sex Traffickers
HONOLULU — Sen. Mazie Hirono, D-Hawaii, is continuing to press law enforcement and other officials to stem the rising tide... Read More
HONOLULU — Sen. Mazie Hirono, D-Hawaii, is continuing to press law enforcement and other officials to stem the rising tide of gender-based violence and sex-trafficking involving Native Hawaiian women and girls. Recently she traveled back to the big island from Washington for discussion on the issue... Read More
January 31, 2023
by TWN Staff
Marburg Vaccine Shows Promising Results in First-In-Human Study
WASHINGTON — An experimental vaccine against Marburg virus, a member of the Ebola virus family that causes death in a... Read More
WASHINGTON — An experimental vaccine against Marburg virus, a member of the Ebola virus family that causes death in a large proportion of infected individuals, proved safe and induced an immune response in a small, first-in-human clinical trial. The findings of the researchers at the National... Read More
January 31, 2023
by Dan McCue
CMS Seeking to Claw Back Improper Medicare Advantage Payments
WASHINGTON — The federal government will begin auditing Medicare Advantage insurers under a new rule finalized Monday, the heightened scrutiny... Read More
WASHINGTON — The federal government will begin auditing Medicare Advantage insurers under a new rule finalized Monday, the heightened scrutiny expected to return as much as $4.7 billion to Medicare’s trust fund over the next 10 years. Watchdog groups had long complained about questionable charges to... Read More
January 31, 2023
by Dan McCue
Administration Moves to Expand Birth Control Coverage Under ACA
WASHINGTON — Women whose employers opted out of covering contraceptives under their health insurance plans on religious grounds could regain... Read More
WASHINGTON — Women whose employers opted out of covering contraceptives under their health insurance plans on religious grounds could regain no-cost access to birth control under new rules proposed by the Biden administration. If implemented, the rules, which were announced under the auspices of the Departments... Read More
January 31, 2023
by Dan McCue
White House Preparing to End COVID-19 Emergencies in May
WASHINGTON — The White House said Monday that President Biden will end dual national emergencies declared to deal with the... Read More
WASHINGTON — The White House said Monday that President Biden will end dual national emergencies declared to deal with the COVID-19 public health crisis in May, nearly three years after they were first declared. The announcement came 24 hours before the Republican-controlled House was to vote... Read More
News From The Well
